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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735536
Species: Homo sapiens
RGD Object: Gene
Symbol: KRT8
Name: keratin 8
Acc ID: CHEBI:91275
Term: N-butyl-N-(4-hydroxybutyl)nitrosamine
Definition: A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.
Chemical ID: MESH:D002085
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRT8decreases expressionISOKrt8 (Mus musculus)6480464CTDButylhydroxybutylnitrosamine results in decreased expression of KRT8 proteinPMID:24998975
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