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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:9123
Term: sertraline
Definition: A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
Chemical ID: MESH:D020280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:691656480464CTDSertraline results in increased expression of DDIT3 mRNA, Sertraline results in increased expression of DDIT3 protein

PMID:24865413
multiple interactionsISORGD:691656480464CTD4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein], MAP4K4 mutant form inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]

PMID:24865413
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.