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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620241
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lef1
Name: lymphoid enhancer binding factor 1
Acc ID: CHEBI:91107
Term: SB 415286
Definition: A member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively.
Chemical ID: MESH:C417520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lef1increases expressionEXP 6480464CTD3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNAPMID:25381574
Lef1multiple interactionsEXP 6480464CTDbisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]PMID:25381574
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