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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2804
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2
Acc ID: CHEBI:91091
Term: CHIR 99021
Definition: A member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively.
Chemical ID: MESH:C473711
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcs2multiple interactionsISOHMGCS2 (Homo sapiens)6480464CTD[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of HMGCS2 mRNA; [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of HMGCS2 mRNAPMID:34480604
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