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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732291
Species: Mus musculus
RGD Object: Gene
Symbol: Fgfr1
Name: fibroblast growth factor receptor 1
Acc ID: CHEBI:91088
Term: orantinib
Definition: An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 2-(2-carboxyethyl)-3,5-dimethylpyrrol-3-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1.
Chemical ID: MESH:C412603
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7322906480464CTDorantinib results in decreased phosphorylation of and results in decreased activity of FGFR1 protein

PMID:16144927
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.