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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:9107
Term: senecionine
Definition: A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.
Chemical ID: MESH:C009237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases expressionISORGD:104516480464CTDsenecionine results in decreased expression of CYP2E1 mRNA

PMID:31606820
Cyp2e1increases expressionISORGD:13450076480464CTDsenecionine results in increased expression of CYP2E1 mRNA

PMID:26100227
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