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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583689
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase family 1 member A5
Acc ID: CHEBI:9107
Term: senecionine
Definition: A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.
Chemical ID: MESH:C009237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a5increases glycosylationISORGD:13435196480464CTDUGT1A4 protein results in increased glycosylation of senecionine

PMID:20092275
Ugt1a5multiple interactionsISORGD:13435196480464CTD[hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine

PMID:20092275
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