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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:9107
Term: senecionine
Definition: A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.
Chemical ID: MESH:C009237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1increases expressionEXP 6480464CTDsenecionine results in increased expression of CYP2E1 mRNAPMID:26100227
CYP2E1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDsenecionine results in decreased expression of CYP2E1 mRNAPMID:31606820
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