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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2267
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Capn1
Name: calpain 1
Acc ID: CHEBI:90951
Term: lumacaftor
Definition: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fibrosis.
Chemical ID: MESH:C569105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Capn1multiple interactionsISOCAPN1 (Homo sapiens)6480464CTDCAPN1 protein affects the reaction [lumacaftor binds to CFTR protein mutant form]PMID:31324722
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