Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:90943
Term: osimertinib
Definition: A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.
Chemical ID: MESH:C000603933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTDosimertinib affects the reaction [EGF protein results in increased phosphorylation of AKT1 protein], osimertinib affects the reaction [EGF protein results in increased phosphorylation of EGFR protein], osimertinib affects the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], osimertinib affects the reaction [EGF protein results in increased phosphorylation of MAPK3 protein], osimertinib affects the reaction [EGF protein results in increased phosphorylation of STAT3 protein]

PMID:30623574
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.