Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631397
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lat2
Name: linker for activation of T cells family, member 2
Acc ID: CHEBI:90942
Term: ixazomib
Definition: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.
Chemical ID: MESH:C548400
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lat2multiple interactionsISORGD:13429146480464CTDixazomib inhibits the reaction [10-octyloxydecyl-2-trimethylammoniumethyl phosphate results in decreased expression of LAT2 protein] ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]

PMID:23001822
Go Back to source page   Continue to Ontology report