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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:9086
Term: (-)-selegiline
Definition: A selegiline that has formula C13H17N.
Chemical ID: MESH:D012642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDSelegiline inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]

PMID:28108387
increases activityISORGD:25036480464CTDSelegiline results in increased activity of NQO1 protein

PMID:22019741
multiple interactionsISORGD:25036480464CTDNFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]], NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein], Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]

PMID:22019741
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.