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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735645
Species: Homo sapiens
RGD Object: Gene
Symbol: BRAF
Name: B-Raf proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:90851
Term: cobimetinib
Definition: A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.
Chemical ID: MESH:C574276
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BRAFincreases response to substanceEXP 6480464CTDBRAF protein mutant form results in increased susceptibility to cobimetinibPMID:22084396
BRAFmultiple interactionsEXP 6480464CTD2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [BRAF protein mutant form results in increased susceptibility to cobimetinib]PMID:22084396
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