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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2702
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glo1
Name: glyoxalase 1
Acc ID: CHEBI:90724
Term: AM-251
Definition: A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Chemical ID: MESH:C103505
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glo1decreases expressionEXP 6480464CTDAM 251 results in decreased expression of GLO1 proteinPMID:26671069
Glo1multiple interactionsEXP 6480464CTDAM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of GLO1 protein]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of GLO1 protein]PMID:26671069
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