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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737354
Species: Homo sapiens
RGD Object: Gene
Symbol: F3
Name: coagulation factor III, tissue factor
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F3decreases expressionEXP 6480464CTDSB 203580 results in decreased expression of F3 mRNAPMID:15371228
F3multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]; SB 203580 inhibits the reaction [Histamine results in increased expression of F3]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of F3 protein]; SB 203580 inhibits the reaction [indoleacetic acid results in increased expression of F3 mRNA]; SB 203580 inhibits the reaction [indoleacetic acid results in increased expression of F3 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of F3 mRNA]PMID:15371228 PMID:16009787 PMID:20118172 PMID:27556861 PMID:30324315
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