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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735753
Species: Mus musculus
RGD Object: Gene
Symbol: Runx2
Name: runt related transcription factor 2
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Runx2multiple interactionsISORunx2 (Rattus norvegicus)6480464CTD[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of RUNX2 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of RUNX2 mRNA]PMID:26136938 PMID:31472278
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