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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases activityISOAKT1 (Homo sapiens)6480464CTDSB 203580 results in decreased activity of AKT1 proteinPMID:10998351
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDSB 203580 results in decreased phosphorylation of AKT1 proteinPMID:27032576 PMID:32060308
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDCannabidiol promotes the reaction [SB 203580 results in decreased phosphorylation of AKT1 protein]; SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; SB 203580 inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein]; SB 203580 inhibits the reaction [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the phosphorylation of AKT1 protein]; SB 203580 inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]PMID:11788791 PMID:15980035 PMID:17341418 PMID:17640974 PMID:27032576 PMID:32060308
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