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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731073
Species: Mus musculus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfamultiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]PMID:22488045 PMID:28329830
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDSB 203580 results in decreased expression of VEGFA mRNA; SB 203580 results in decreased expression of VEGFA proteinPMID:13679210 PMID:30801954
Vegfamultiple interactionsISOVegfa (Rattus norvegicus)6480464CTDSB 203580 inhibits the reaction [[Calcitriol co-treated with TGFB1 protein] results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Calcitriol results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased secretion of VEGFA protein]PMID:16598785
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]]; SB 203580 inhibits the reaction [Melitten results in decreased expression of VEGFA protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [Troglitazone results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [Troglitazone results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]PMID:12482858 PMID:13679210 PMID:18252963 PMID:18596194 PMID:18599600 PMID:23110475 PMID:23968725 PMID:32890875
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