Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP2decreases expressionEXP 6480464CTDSB 203580 results in decreased expression of MMP2PMID:23707804
MMP2multiple interactionsEXP 6480464CTDbrazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; SB 203580 affects the reaction [U 0126 promotes the reaction [Plant Extracts results in decreased expression of MMP2 protein]]; SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Air Pollutants results in increased activity of MMP2 protein]]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Particulate Matter results in increased activity of MMP2 protein]]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [taiwanin E results in decreased expression of MMP2 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; SB 203580 promotes the reaction [Resveratrol results in decreased expression of and results in decreased activity of MMP2 protein]; SB 203580 promotes the reaction [Resveratrol results in decreased expression of MMP2]; SB 203580 results in decreased expression of and results in decreased activity of MMP2 proteinPMID:20599481 PMID:21635667 PMID:23707804 PMID:24841706 PMID:24929186 PMID:25605016 PMID:26179980 PMID:27807932 PMID:28181379
MMP2affects expressionISOMmp2 (Rattus norvegicus)6480464CTDSB 203580 affects the expression of MMP2 mRNA; SB 203580 affects the expression of MMP2 proteinPMID:16575906
Go Back to source page   Continue to Ontology report