Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1amultiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CDKN1A protein]PMID:14603533 PMID:21600278
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTDSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of CDKN1A mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]PMID:11807808 PMID:15882963 PMID:17108117 PMID:28329830
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Cadmium results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]PMID:14647439 PMID:15734884 PMID:19082730
Go Back to source page   Continue to Ontology report