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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69127
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl5multiple interactionsISOCCL5 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]]; SB 203580 inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL5 protein]; SB 203580 inhibits the reaction [Particulate Matter analog results in increased secretion of CCL5 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Vehicle Emissions analog results in increased secretion of CCL5 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter analog results in decreased secretion of CCL5 protein]]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions analog results in decreased secretion of CCL5 protein]]; SB 203580 promotes the reaction [Methotrexate results in increased expression of CCL5 protein]PMID:10919993 PMID:11167962 PMID:16908450 PMID:19100307
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