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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:104736480464CTDpyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 mRNA], pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 protein], pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 mRNA], pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 protein], pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 mRNA], pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 protein]

PMID:18752316
multiple interactionsISORGD:25036480464CTDpyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NQO1 mRNA]

PMID:29426002
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.