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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731380
Species: Homo sapiens
RGD Object: Gene
Symbol: AIFM1
Name: apoptosis inducing factor mitochondria associated 1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AIFM1multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [arsenic trioxide affects the localization of AIFM1 protein]PMID:18412143
AIFM1multiple interactionsISOAifm1 (Rattus norvegicus)6480464CTDpyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of AIFM1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]PMID:24577723 PMID:25043952 PMID:29289695
AIFM1multiple interactionsISOAifm1 (Mus musculus)6480464CTDpyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]PMID:20423716
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