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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3decreases activityEXP 6480464CTDpyrazolanthrone results in decreased activity of CASP3 proteinPMID:15095415
CASP3increases activityEXP 6480464CTDpyrazolanthrone results in increased activity of CASP3 proteinPMID:15034932
CASP3increases expressionEXP 6480464CTDpyrazolanthrone results in increased expression of CASP3 protein modified formPMID:28383207
CASP3multiple interactionsEXP 6480464CTD[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Citrinin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Phytochemicals results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [pachastrissamine analog results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [picrasidine I results in increased expression of CASP3 protein modified form]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein]PMID:12393500 PMID:15501958 PMID:15767555 PMID:15831436 PMID:15850772 PMID:16061660 PMID:16357177 PMID:16843435 PMID:17341418 PMID:18281123 PMID:18767140 PMID:19193634 PMID:19361540 PMID:19631732 PMID:20632440 PMID:21165570 PMID:21843585 PMID:22654482 PMID:23082001 PMID:23212307 PMID:23416140 PMID:23836369 PMID:24036456 PMID:25078063 PMID:25305377 PMID:25446857 PMID:26630137 PMID:27539140 PMID:28474156 PMID:29968959 PMID:30871965 PMID:31044527 PMID:31421117 PMID:32652169 PMID:33035517 PMID:33959992 PMID:34894061 PMID:35123989
CASP3multiple interactionsISOCasp3 (Mus musculus)6480464CTD6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [pseudolaric acid B results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]PMID:15254339 PMID:16322078 PMID:16712891 PMID:23578390 PMID:24157283 PMID:25882087 PMID:31447676 PMID:33684387 PMID:37244295
CASP3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDpyrazolanthrone inhibits the reaction [4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [bakuchiol results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [satratoxin H results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Thrombin results in increased expression of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; Taurine promotes the reaction [pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]]PMID:16310883 PMID:16787641 PMID:17292878 PMID:18703135 PMID:20830294 PMID:20920558 PMID:21295052 PMID:21600974 PMID:21843586 PMID:22863859 PMID:23405080 PMID:24111524 PMID:24577723 PMID:25043952 PMID:26588882 PMID:27841083 PMID:28391263 PMID:29289695 PMID:30259999 PMID:30928397 PMID:32574669 PMID:33922211 PMID:35172196
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