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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10812
Species: Mus musculus
RGD Object: Gene
Symbol: Ins2
Name: insulin II
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [GW8510 results in increased expression of INS2 mRNA]PMID:22242153
Ins2multiple interactionsISOIns2 (Rattus norvegicus)6480464CTDpyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]PMID:17728140
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