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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDpyrazolanthrone results in increased expression of CYP1A2 mRNAPMID:17959153
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [pyrazolanthrone results in increased expression of CYP1A2 mRNA]PMID:17959153
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