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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:90686
Term: IC-87114
Definition: A member of the class of quinazolines that is quinazolin-4(3H)-one carrying (6-amino-9H-purin-9-yl)methyl, 2-methylphenyl and methyl substituents at positions 2, 3 and 5 respectively.
Chemical ID: MESH:C477872
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107966480464CTDIC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein], IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein], IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein], IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]

PMID:16179367
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.