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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:90677
Term: GSK690693
Definition: A member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively.
Chemical ID: MESH:C528328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1decreases phosphorylationISOEIF4EBP1 (Homo sapiens)6480464CTDGSK690693 results in decreased phosphorylation of EIF4EBP1 proteinPMID:22532600
Eif4ebp1multiple interactionsISOEIF4EBP1 (Homo sapiens)6480464CTD[sunitinib co-treated with GSK690693] results in decreased phosphorylation of EIF4EBP1 proteinPMID:22532600
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