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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:90633
Term: perfluorododecanoic acid
Definition: A fluoroalkanoic acid that is dodecanoic acid in which all of the hydrogens attached to carbon atoms are replaced by fluorines. It is a highly persistent, bioaccumulative breakdown product of stain- and grease-proof coatings on food packaging, soft furnishings and carpets.
Chemical ID: MESH:C522391
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3baffects response to substanceISOGsk3b (Rattus norvegicus)6480464CTDGSK3B protein affects the susceptibility to perfluorododecanoic acidPMID:23353032
Gsk3bdecreases expressionISOGsk3b (Rattus norvegicus)6480464CTDperfluorododecanoic acid results in decreased expression of GSK3B protein; perfluorododecanoic acid results in decreased expression of GSK3B protein modified formPMID:23353032
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