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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1623316
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Acc ID: CHEBI:90633
Term: perfluorododecanoic acid
Definition: A fluoroalkanoic acid that is dodecanoic acid in which all of the hydrogens attached to carbon atoms are replaced by fluorines. It is a highly persistent, bioaccumulative breakdown product of stain- and grease-proof coatings on food packaging, soft furnishings and carpets.
Chemical ID: MESH:C522391
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp4a12bincreases expressionISOCyp4a1 (Rattus norvegicus)6480464CTDperfluorododecanoic acid results in increased expression of CYP4A1 mRNAPMID:26168851
Cyp4a12bmultiple interactionsISOCyp4a1 (Rattus norvegicus)6480464CTDperfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of CYP4A1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of CYP4A1 mRNA]PMID:26168851
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