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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620763
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn1
Name: cellular communication network factor 1
Acc ID: CHEBI:9053
Term: sclareol
Definition: A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.
Chemical ID: MESH:C070760
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn1increases expressionISOCcn1 (Mus musculus)6480464CTDsclareol results in increased expression of CCN1 mRNA; sclareol results in increased expression of CCN1 proteinPMID:33423118
Ccn1multiple interactionsISOCcn1 (Mus musculus)6480464CTD[sclareol co-treated with SB 203580] results in increased expression of CCN1 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]PMID:33423118
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