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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319357
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfatc1
Name: nuclear factor of activated T-cells 1
Acc ID: CHEBI:9053
Term: sclareol
Definition: A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.
Chemical ID: MESH:C070760
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfatc1decreases expressionISONfatc1 (Mus musculus)6480464CTDsclareol results in decreased expression of NFATC1 mRNA; sclareol results in decreased expression of NFATC1 proteinPMID:33423118
Nfatc1multiple interactionsISONfatc1 (Mus musculus)6480464CTDsclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]PMID:33423118
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