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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:90528
Term: VX-745
Definition: A member of the class of pyrimidopyridazines that is 6H-pyrimido[1,6-b]pyridazin-6-one substituted at positions 2 and 5 by (2,4-difluorophenyl)sulfanyl and 2,6-dichlorophenyl groups respectively
Chemical ID: MESH:C464966
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6decreases secretionISORGD:13525826480464CTDVX-745 results in decreased secretion of IL6 protein

PMID:12393542
Il6multiple interactionsISORGD:13525826480464CTDVX-745 inhibits the reaction [TNF protein results in increased secretion of IL6 protein]

PMID:12393542
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