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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:90369
Term: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Definition: A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.
Chemical ID: MESH:C550547
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]PMID:37436358
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IL6 mRNA]PMID:37436145
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased secretion of IL6 protein]PMID:31981641
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