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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:90369
Term: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Definition: A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.
Chemical ID: MESH:C550547
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 proteinPMID:29653943 PMID:35307491
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased expression of BCL2 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide co-treated with [Potassium Dichromate results in increased abundance of chromium hexavalent ion]] results in decreased expression of BCL2 protein; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 protein]PMID:29653943 PMID:31433112 PMID:33661552 PMID:35307491
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]PMID:37436358
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