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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:90217
Term: quizartinib
Definition: A member of the class of phenylureas that is urea in which one of the amino groups has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group while the other has been substituted by a phenyl group substituted at the para- position by an imidazo[2,1-b][1,3]benzothiazol-2-yl group that, in turn, is substituted at position 7 by a 2-(morpholin-4-yl)ethoxy group.
Chemical ID: MESH:C544967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDquizartinib results in decreased expression of CDKN1A proteinPMID:34665271
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDquizartinib results in increased expression of CDKN1A proteinPMID:25053825
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD(+)-JQ1 compound promotes the reaction [quizartinib results in increased expression of CDKN1A protein]; quizartinib inhibits the reaction [RGFP966 results in increased expression of CDKN1A protein]; quizartinib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein]PMID:25053825 PMID:34665271
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