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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1a
Name: interleukin 1 alpha
Acc ID: CHEBI:8984
Term: sodium dodecyl sulfate
Definition: An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.
Chemical ID: MESH:D012967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1adecreases expressionISOIL1A (Homo sapiens)6480464CTDSodium Dodecyl Sulfate results in decreased expression of IL1A proteinPMID:19878710
Il1aincreases expressionISOIL1A (Homo sapiens)6480464CTDSodium Dodecyl Sulfate results in increased expression of IL1A mRNA; Sodium Dodecyl Sulfate results in increased expression of IL1A proteinPMID:11378323 PMID:12781210 PMID:25290854 PMID:33839235
Il1aincreases secretionISOIL1A (Homo sapiens)6480464CTDSodium Dodecyl Sulfate results in increased secretion of IL1A proteinPMID:12781210 PMID:15679580
Il1amultiple interactionsISOIL1A (Homo sapiens)6480464CTDIL1A protein affects the reaction [Sodium Dodecyl Sulfate results in increased secretion of CCL20 protein]; IL1A protein affects the reaction [Sodium Dodecyl Sulfate results in increased secretion of CXCL8 protein]; Sodium Dodecyl Sulfate results in increased expression of and results in increased secretion of IL1A proteinPMID:15679580 PMID:21469165
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