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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:8899
Term: rottlerin
Definition: A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.
Chemical ID: MESH:C085746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDrottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA], rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 protein], rottlerin inhibits the reaction [Plant Extracts results in increased expression of NQO1 protein]

PMID:21787730, PMID:30626086
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.