Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621612
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nts
Name: neurotensin
Acc ID: CHEBI:8899
Term: rottlerin
Definition: A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.
Chemical ID: MESH:C085746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:13190926480464CTDrottlerin results in increased activity of NTS protein

PMID:18313772
multiple interactionsISORGD:13190926480464CTDrottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates], rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein], rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein], rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein], rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:15177934, PMID:18313772
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.