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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:8899
Term: rottlerin
Definition: A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.
Chemical ID: MESH:C085746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1multiple interactionsEXP 6480464CTDrottlerin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]PMID:27658547
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDrottlerin results in increased cleavage of PARP1 proteinPMID:22902833
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTD[rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 proteinPMID:35995259
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