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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735879
Species: Mus musculus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:8874
Term: rivastigmine
Definition: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
Chemical ID: MESH:C072506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acheaffects activityISOAche (Rattus norvegicus)6480464CTDRivastigmine affects the activity of ACHE proteinPMID:12111444
Achedecreases activityISOAche (Rattus norvegicus)6480464CTDRivastigmine results in decreased activity of ACHE proteinPMID:15135892 PMID:18571635 PMID:19345205 PMID:30588862
Achedecreases activityISOACHE (Homo sapiens)6480464CTDRivastigmine results in decreased activity of ACHE proteinPMID:32092302 PMID:33037899
Achemultiple interactionsISOAche (Rattus norvegicus)6480464CTDAFDX 384 affects the reaction [Rivastigmine affects the activity of ACHE protein]; Rivastigmine inhibits the reaction [[Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine]; Rivastigmine inhibits the reaction [Aluminum Chloride results in increased activity of ACHE protein]; Rivastigmine inhibits the reaction [Aluminum Chloride results in increased expression of ACHE mRNA]; Rivastigmine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]PMID:12111444 PMID:32805344 PMID:34663170 PMID:37507053
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