GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Drd2 | affects binding | EXP | | 6480464 | CTD | Risperidone binds to DRD2 protein | PMID:12191584 PMID:22437487 PMID:8804920 | Drd2 | multiple interactions | EXP | | 6480464 | CTD | [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]; Risperidone binds to and results in decreased activity of DRD2 protein; Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]; Risperidone promotes the reaction [Dopamine binds to DRD2 protein] | PMID:1380082 PMID:15716360 PMID:16033416 PMID:16144542 PMID:7520908 | Drd2 | affects binding | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Risperidone binds to DRD2 protein | PMID:10831489 PMID:15710053 PMID:16513859 PMID:18058087 PMID:19640686 PMID:20361897 PMID:22967779 PMID:8804920 | Drd2 | affects response to substance | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | DRD2 gene polymorphism affects the susceptibility to Risperidone | PMID:21869689 | Drd2 | increases response to substance | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | DRD2 gene polymorphism results in increased susceptibility to Risperidone; DRD2 gene SNP results in increased susceptibility to Risperidone; DRD2 protein results in increased susceptibility to Risperidone | PMID:19339912 PMID:20375926 PMID:21869689 | Drd2 | multiple interactions | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Risperidone binds to and results in decreased activity of DRD2 protein | PMID:19910723 | |
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