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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:8871
Term: risperidone
Definition: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Chemical ID: MESH:D018967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects bindingEXP 6480464CTDRisperidone binds to DRD2 proteinPMID:12191584 PMID:22437487 PMID:8804920
Drd2multiple interactionsEXP 6480464CTD[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]; Risperidone binds to and results in decreased activity of DRD2 protein; Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]; Risperidone promotes the reaction [Dopamine binds to DRD2 protein]PMID:1380082 PMID:15716360 PMID:16033416 PMID:16144542 PMID:7520908
Drd2affects bindingISODRD2 (Homo sapiens)6480464CTDRisperidone binds to DRD2 proteinPMID:10831489 PMID:15710053 PMID:16513859 PMID:18058087 PMID:19640686 PMID:20361897 PMID:22967779 PMID:8804920
Drd2affects response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 gene polymorphism affects the susceptibility to RisperidonePMID:21869689
Drd2increases response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 gene polymorphism results in increased susceptibility to Risperidone; DRD2 gene SNP results in increased susceptibility to Risperidone; DRD2 protein results in increased susceptibility to RisperidonePMID:19339912 PMID:20375926 PMID:21869689
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTDRisperidone binds to and results in decreased activity of DRD2 proteinPMID:19910723
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