GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | increases activity | EXP | | 6480464 | CTD | butylparaben results in increased activity of PPARG protein | PMID:28527915 | Pparg | increases expression | EXP | | 6480464 | CTD | butylparaben results in increased expression of PPARG mRNA | PMID:22956630 PMID:27659731 PMID:28527915 | Pparg | increases response to substance | EXP | | 6480464 | CTD | PPARG protein results in increased susceptibility to butylparaben | PMID:28527915 | Pparg | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [butylparaben results in increased expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [butylparaben results in increased expression of PPARG mRNA]; butylparaben promotes the reaction [Dexamethasone results in increased expression of PPARG mRNA]; Mifepristone inhibits the reaction [butylparaben results in increased expression of PPARG mRNA]; PPARG mutant form inhibits the reaction [butylparaben results in increased expression of FABP4 mRNA]; PPARG mutant form inhibits the reaction [butylparaben results in increased expression of PLIN1 mRNA]; PPARG protein inhibits the reaction [butylparaben results in decreased expression of SPP1 mRNA]; PPARG protein promotes the reaction [butylparaben binds to and results in increased activity of PPARG protein]; PPARG protein promotes the reaction [butylparaben results in decreased expression of ALPL mRNA]; PPARG protein promotes the reaction [butylparaben results in increased expression of CEBPA mRNA]; PPARG protein promotes the reaction [butylparaben results in increased expression of FABP4 mRNA]; PPARG protein promotes the reaction [butylparaben results in increased expression of PLIN1 mRNA] | PMID:22956630 PMID:24155963 PMID:28527915 | Pparg | increases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | butylparaben results in increased expression of PPARG mRNA | PMID:22956630 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | butylparaben binds to and results in increased activity of PPARG protein | PMID:24155963 | | ||||||||||||||||||||||
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