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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68557
Species: Mus musculus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:88339
Term: BMS-754807
Definition: A pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases.
Chemical ID: MESH:C545990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1increases response to substanceISOCCND1 (Homo sapiens)6480464CTDCCND1 mutant form results in increased susceptibility to BMS 754807PMID:24986516
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD[BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 proteinPMID:24986516
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