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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:88249
Term: PD 0325901
Definition: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Chemical ID: MESH:C506614
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDmirdametinib results in increased phosphorylation of AKT1 proteinPMID:27634878
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[mirdametinib co-treated with MK 2206] results in increased phosphorylation of AKT1 protein; [mirdametinib co-treated with silmitasertib] results in decreased phosphorylation of AKT1 protein; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]; romidepsin inhibits the reaction [[mirdametinib co-treated with MK 2206] results in increased phosphorylation of AKT1 protein]PMID:22415236 PMID:25798061 PMID:27634878
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