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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:88217
Term: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Definition: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Chemical ID: MESH:C044387
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7355366480464CTDN, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA

PMID:18778698
multiple interactionsISORGD:7355366480464CTDTP53 mutant form inhibits the reaction [N, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA]

PMID:18778698
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.