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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735652
Species: Homo sapiens
RGD Object: Gene
Symbol: AR
Name: androgen receptor
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARaffects expressionEXP 6480464CTDRaloxifene Hydrochloride affects the expression of AR mRNAPMID:27163517
ARdecreases expressionEXP 6480464CTDRaloxifene Hydrochloride results in decreased expression of AR mRNA; Raloxifene Hydrochloride results in decreased expression of AR proteinPMID:11867264 PMID:27163517
ARmultiple interactionsEXP 6480464CTD[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of AR proteinPMID:27163517
ARdecreases expressionISOAr (Rattus norvegicus)6480464CTDRaloxifene Hydrochloride results in decreased expression of AR proteinPMID:15731164 PMID:16837883
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