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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1affects expressionISOTimp1 (Rattus norvegicus)6480464CTDRaloxifene Hydrochloride affects the expression of TIMP1 mRNAPMID:16079270
Timp1increases expressionISOTIMP1 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in increased expression of TIMP1 mRNA; Raloxifene Hydrochloride results in increased expression of TIMP1 proteinPMID:16202921 PMID:21935668
Timp1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTD[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of TIMP1 proteinPMID:31332895
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