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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62288
Species: Mus musculus
RGD Object: Gene
Symbol: F2
Name: coagulation factor II
Acc ID: CHEBI:8714
Term: quinapril hydrochloride
Definition: A hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure.
Chemical ID: MESH:C041125
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2decreases activityISOF2 (Homo sapiens)6480464CTDQuinapril results in decreased activity of F2 proteinPMID:16907931
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