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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:86989
Term: stattic
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma.
Chemical ID: MESH:C517409
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3multiple interactionsEXP 127284846RGDStattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach) 
STAT3decreases phosphorylationEXP 6480464CTDstattic results in decreased phosphorylation of STAT3 proteinPMID:24627483
STAT3multiple interactionsEXP 6480464CTDstattic affects the reaction [Arsenicals affects the phosphorylation of STAT3 protein]; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]PMID:23255093 PMID:24627483 PMID:25740948 PMID:29341321
STAT3multiple interactionsISOStat3 (Rattus norvegicus)6480464CTDstattic inhibits the reaction [zoniporide results in increased phosphorylation of STAT3 protein]PMID:20942815
STAT3multiple interactionsISOStat3 (Mus musculus)6480464CTDstattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]PMID:22454431 PMID:25740948 PMID:28739487
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